![]() We anticipate initiating other clinical trials based upon these observations. She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. She observed a significant number of responders in this trial (54). Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. These observations may be of clinical relevance. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. Basic laws of physics, including Newtons laws of motion and gravitation, laws. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. Relatives of Audie Strotkamp in Bel Aire, KS Jeanne Strotkamp Cathy Strotkamp Charles Strotkamp Christina Mcdulin Gary Strotkamp Glen Strotkamp Jennifer. The studies with cis-DDP and ~-DDP in combination with UVĀ induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. University of Kansas - Jayhawker Yearbook (Lawrence, KS), Class of 1994, Cover has the largest online yearbook collection of college, university, high school, middle school, junior high school, military, naval cruise books and yearbooks. Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds.
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